학력
서울대학교 수의과대학 졸업 (D.V.M.)
고려대학교 의학전문대학원 졸업 (M.D.)
Hokkaido University 대학원 박사 (Ph.D.) (2005)
주요경력
現 대한임상약리학회 정회원(임상약리학 인정의)
前 서울아산병원 임상약리학과 연수의사
前 National Institutes of Health(NIH) Clinical center(Bethesda, Maryland), Fellow
前 식품의약품안전청 국립독성과학원 보건연구사
연구실적
Development of examination objectives for the Korean paramedic and emergency medical technician examination: a survey study. J Educ Eval Health Prof. (2024).
Pharmacokinetic interactions between bazedoxifene and cholecalciferol: an open-label, randomized, crossover study in healthy male volunteers. Drug Des Devel Ther. (2023).
Pharmacokinetic and pharmacodynamic modeling and simulation analysis of prasugrel in healthy male volunteer. Clin Pharmacol Drug Dev. (2023).
Pharmacokinetic drug interaction between amlodipine and tadalafil: an open-label, randomized, multiple-dose, crossover study in healthy male volunteer. Drug Des Devel Ther. (2022).
Trends of clinical trials from 2017 to 2019 in Korea: an integrated analysis based on the Ministry of Food and Drug Safety (MFDS) and the clinical Research Information Service (CRIS) registries. Transl Clin Pharmacol. (2021).
Acetaminophen-induced anaphylaxis: a case report. Transl Clin Pharmacol. (2021).
Bioequivalence data analysis. Transl Clin Pharmacol. (2020).
Validation of “sasLM”, an R package for linear models with type III sum of square. Transl Clin Pharmacol. (2020).
Disease progression modeling analysis of the change of bone mineral density by postoperative hormone therapies in postmenopausal patients with early breast cancer. J Clin Pharmacol. (2019).
Single-dose intravenous safety, tolerability and pharmacokinetics and absolute bioavailability of LCB01-0371. Clin Ther. (2019).
Pharmacokinetic interactions and tolerability of coadministration of rosuvastatin and ezetimibe: an open, randomized, multiple-dose, crossover study in healthy male volunteer. Drug Des Devel Ther. (2018).
Development of R packages: ‘NonCompart’ and ‘ncar’ for Noncompartmental analysis (NCA). Transl Clin Pharmacol. (2018).
Caffsim: Simulation of plasma caffeine concentrations implemented as an R package and Web-applications. Transl Clin Pharmacol. (2017).
Protective effect of resveratrol against cisplatin-induced ototoxicity in HEI-OC1 auditory cells. Int J Pediatr Otorhinolaryngol. (2015).
Pulsed high intensity focused ultrasound increases penetration and therapeutic efficacy of monoclonal antibodies in murine xenograft tumors. J Control Release. (2012).
Combined-modality radioimmunotherapy: synergistic effect of paclitaxel and additive effect of bevacizumab. Nucl Med Biol. (2012).
Effect of chelator conjugation level and injection dose on tumor and organ uptake of 111In-labeled MORAb-009, an anti-mesothelin antibody. Nucl Med Biol. (2011).
Induction of apoptosis and CYP4A1 expression in Sprague-Dawley (SD) rats exposed to low doses of perfluorooctane sulfonate (PFOS). J Toxicol Sci. (2011).
Diazepam metabolism in kidney of male and female rats of varying strain. J Vet Med Sci. (2010).
Di-(2-ethylhexyl) phthalate (DEHP) suppresses Tamoxifen-induced apoptosis in GH3 pituitary cells. Arch Toxicol. (2007).
Importance of CYP2D3 in polymorphism of diazepam p-hydroxylation in rats. Drug Metab Dispos. (2005).
AhR and PPARa: Antagonistic effects on CYP2B and CYP3A, and additive inhibitory effects on CYP2C11. Xenobiotica. (2005).
Strain differences in diazepam metabolism at its three metabolic sites in Sprague-Dawley, Brown Norway, Dark Agouti, and Wistar strain rats. Drug Metab Dispos. (2004).
Alterations in activities of cytosolic phospholipase A2 and arachidonic acid-metabolizing enzymes in di-(2-ethylhexyl) phthalate-induced testicular atrophy. J Vet Med Sci. (2004).
Polymorphism in diazepam metabolism in Wistar rats. J Pharm Sci. (2004).
Short period exposure to di-(2-ethylhexyl) phthalate regulates testosterone metabolism in prepubertal rats Testis. Arch Toxicol. (2003).
Di-(2-ethylhexyl) phthalate-induced cell proliferation is involved in the inhibition of gap junctional intercellular communication (GJIC) and blockage of apoptosis in mouse Sertoli cells. J Toxicol Environ Health A. (2002).
Immature uterotrophic assay is more sensitive than ovariectomized uterotrophic assay for the detection of estrogenicity of p-nonylphenol in Sprague-Dawley rats. Toxicol Lett. (2000).